Image Processing Application Development: From Rapid Prototyping to SW/HW Co-simulation and Automated Code Generation

Nowadays, the market-place offers quite powerful and low cost reconfigurable hardware devices and a wide range of software tools which find application in the image processing field. However, most of the image processing application designs and their latter deployment on specific hardware devices is still carried out quite costly by hand. This paper presents a new approach to image processing application development, which tackles the historic question of how filling the gap existing between rapid throwaway software designs and final software/hardware implementations. A new graphical component-based tool has been implemented which allows to comprehensively develop this kind of applications, from functional and architectural prototyping stages to software/hardware co-simulation and final code generation. Building this tool has been possible thanks to the synergy that arises from the integration of several of the pre-existent software and hardware image processing libraries and tools.COSIVA (TIC 2000-1765-C03-02),EFTCOR (DPI2002-11583-E), PMPDI-UPCT-2004Escuela Técnica Superior de Ingeniería de Telecomunicació

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men